Based on what I've learned about Sarah Palin's record and from what I've observed in her two introductory speeches, Palin's addition to the McCain ticket turbo-charges the Obama/Biden "more of the same" argument against McCain.
A McCain Administration seemed certain to simply extend Bush policies, with McCain having compromised his alleged principles on so many critical issues... but Sarah Palin is apparently the embodiment of the hyper-partisan, fact-averse, loyalty-over-competence, abuse of power, cancerous politics we've seen in abundance from the Bush Administration and the Republican Party for the last 8 years.
Truly, Sarah Palin completes McSame.